From the time when the first cases of COVID-19 were reported in Wuhan City, China, in December 2019, strict regulations are being implemented by policy makers to contain the spread of the virus. The measures taken in different countries spanned from complete isolation and lockdown to different degrees of restrictions to people's movement, contact between people, hygiene and sanitation. Accordingly, the success in containing the virus also differed. Italy was one among the worst-affected countries in the world despite the lockdown measures adopted. A combination of lockdown and Level-3 State of Emergency measures were adopted in Portugal and South Africa, which helped to delay and flatten the epidemic curve. The timely application of Level-3 State of Emergency in Mozambique resulted in recording low infection rates. Above all the tripod, orderly movement of people, social distance and hygiene and sanitation is the keystone measure to prevent spread of the virus. However, for successful outcome, the measures have to be tailored to the local context.