Abstract
The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA and vinyl-quinazolinone-S(O)Me (6OTD-VQ-S(O)Me).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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DNA / chemical synthesis*
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DNA / chemistry
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G-Quadruplexes
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Macrocyclic Compounds / chemistry*
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Molecular Structure
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Oxazoles / chemistry*
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Quinazolinones / chemistry*
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Vinyl Compounds / chemistry*
Substances
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Macrocyclic Compounds
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Oxazoles
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Quinazolinones
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Vinyl Compounds
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DNA