Platelet Dysfunction During Mechanical Circulatory Support: Elevated Shear Stress Promotes Downregulation of αIIbβ3 and GPIb via Microparticle Shedding Decreasing Platelet Aggregability

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1319-1336. doi: 10.1161/ATVBAHA.120.315583. Epub 2021 Feb 11.

Abstract

[Figure: see text].

Keywords: adhesion receptor; flow cytometry; heart failure; platelet aggregation; thrombosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism*
  • Cell-Derived Microparticles / drug effects
  • Cell-Derived Microparticles / metabolism*
  • Down-Regulation
  • Female
  • Humans
  • Male
  • Mechanotransduction, Cellular*
  • Oligopeptides / pharmacology
  • P-Selectin / blood
  • Platelet Aggregation* / drug effects
  • Platelet Glycoprotein GPIIb-IIIa Complex / metabolism*
  • Platelet Glycoprotein GPIb-IX Complex / metabolism*
  • Stress, Mechanical

Substances

  • Oligopeptides
  • P-Selectin
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Glycoprotein GPIb-IX Complex
  • SELP protein, human
  • Ser-Phe-Phe-Leu-Arg-Asn
  • Adenosine Diphosphate