Unravelling Toxoplasma treatment: conventional drugs toward nanomedicine

World J Microbiol Biotechnol. 2021 Feb 10;37(3):48. doi: 10.1007/s11274-021-03000-x.

Abstract

Toxoplasma gondii is a worldwide protozoan parasite that infects almost all warm-blooded animals. Although human toxoplasmosis is mostly latent, pregnant women and immunocompromised patients need effective treatment. There are drugs of choice for treatment of toxoplasmosis; however, due to their side effects and/or their disease stage-specificity, prescription of them is limited. During recent years, nanomedicine has been employed to overcome limitations of conventional drugs. Here, we provided a state-of-the-art review of experimental toxoplasmosis treatment using nanotechnology.

Keywords: Acute toxoplasmosis; Chronic toxoplasmosis; Conventional therapy; Nanomedicine; Toxoplasma gondii; Treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Nanomedicine*
  • Pharmaceutical Preparations
  • Toxoplasma / drug effects*
  • Toxoplasmosis / drug therapy*
  • Toxoplasmosis / parasitology
  • Treatment Outcome
  • Zoonoses / parasitology

Substances

  • Pharmaceutical Preparations