Breakthroughs and Bottlenecks in Microbiome Research

Timur Liwinski; Avner Leshem; Eran Elinav

doi:10.1016/j.molmed.2021.01.003

Breakthroughs and Bottlenecks in Microbiome Research

Trends Mol Med. 2021 Apr;27(4):298-301. doi: 10.1016/j.molmed.2021.01.003. Epub 2021 Feb 6.

Authors

Timur Liwinski¹, Avner Leshem², Eran Elinav³

Affiliations

¹ Immunology Department, Weizmann Institute of Science, Rehovot, 7610001, Israel; 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² Immunology Department, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
³ Immunology Department, Weizmann Institute of Science, Rehovot, 7610001, Israel; Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ), Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address: eran.elinav@weizmann.ac.il.

PMID: 33563544
DOI: 10.1016/j.molmed.2021.01.003

Abstract

Over the past 15 years, the research community has witnessed unprecedented progress in microbiome research. We review this increasing knowledge and first attempts of its clinical application, and also limitations and challenges faced by the research community, in mechanistically understanding host-microbiome interactions and integrating these insights into clinical practice.

Keywords: microbiome; microbiota; precision medicine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diet
Fecal Microbiota Transplantation
Host Microbial Interactions
Humans
Metagenomics / methods
Microbiota* / drug effects
Microbiota* / genetics
Microbiota* / immunology
Phage Therapy
Precision Medicine / trends
Probiotics