Sleep: AMPs Mediate Injury-Induced Lethargy

Jeremy J Grubbs; David M Raizen

doi:10.1016/j.cub.2020.11.048

Sleep: AMPs Mediate Injury-Induced Lethargy

Curr Biol. 2021 Feb 8;31(3):R131-R133. doi: 10.1016/j.cub.2020.11.048.

Authors

Jeremy J Grubbs¹, David M Raizen²

Affiliations

¹ Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 347B CRB Building, 415 Curie Boulevard, Philadelphia, PA 19104-4283, USA; Chronobiology and Sleep Institute, University of Pennsylvania, SCTR 10-142, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
² Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 347B CRB Building, 415 Curie Boulevard, Philadelphia, PA 19104-4283, USA; Chronobiology and Sleep Institute, University of Pennsylvania, SCTR 10-142, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: raizen@pennmedicine.upenn.edu.

PMID: 33561412
DOI: 10.1016/j.cub.2020.11.048

Abstract

Fatigue and sleepiness are widely observed but ill-understood responses to tissue injury. A new study in Caenorhabditis elegans illuminates how the innate immune system mediates injury-induced sleep, which may help in surviving the injury.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins*
Humans
Lethargy / etiology
Sleep
Wakefulness

Substances

Caenorhabditis elegans Proteins

Grants and funding

P40 OD010440/OD/NIH HHS/United States