SARS-CoV-2 pneumonia-receptor binding and lung immunopathology: a narrative review

Crit Care. 2021 Feb 8;25(1):53. doi: 10.1186/s13054-020-03399-z.

Abstract

The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.

Keywords: ACE2; Acute respiratory distress syndrome; COVID-19; Hypercoagulability; Immunology; Pathology; SARS-CoV-2 pneumonia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • COVID-19 / immunology
  • COVID-19 / physiopathology*
  • Carrier Proteins / immunology
  • Carrier Proteins / physiology*
  • Humans
  • Lung Diseases / immunology
  • Lung Diseases / physiopathology*
  • Pandemics
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / physiopathology*
  • SARS-CoV-2 / immunology
  • SARS-CoV-2 / pathogenicity*

Substances

  • Carrier Proteins