Novel Nitrogen Containing Steroid Derivatives for Prostate Cancer Treatment

Abstract

This mini-review focuses on the investigation of novel nitrogen-containing steroid derivatives that are potentially applicable for prostate cancer treatment. It covers the literature of the last decade, highlighting the structure of new steroid compounds that exhibit significant activity in prostate cancer cells and possess pharmacological potency. New derivatives of known anti-prostate cancer agents: abiraterone and galeterone, new derivatives of androstane and pregnane modified with nitrogen-containing heterocycles, and some related steroid-derived compounds are discussed in the review.

Keywords: Prostate cancer; abiraterone; androgen deprivation therapy.; anti-prostate cancer agents; galeterone; novel nitrogen; steroid CYP17A1 inhibitors.