The hypothesis of tumor-associated macrophages mediating semi-phagocytosis of cancer cells in distant metastasis

Future Oncol. 2021 Apr;17(10):1125-1129. doi: 10.2217/fon-2020-1101. Epub 2021 Feb 9.

Abstract

Tweetable abstract Tumor-associated macrophages might promote the distant metastasis of tumor cells by semi-phagocytosis. The authors propose that this newly discovered process occurs in tumor-associated macrophages and may lead to a novel approach for blocking cancer metastasis.

Keywords: aging macrophages; cancer metastasis; circulating tumor cells; premetastatic niches; semi-phagocytosis; tumor-associated macrophages.

Publication types

  • Editorial
  • Letter

MeSH terms

  • Animals
  • Humans
  • Neoplasm Metastasis
  • Neoplasms / immunology*
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Neoplastic Cells, Circulating / immunology
  • Phagocytosis / immunology*
  • Tumor Microenvironment / immunology*
  • Tumor-Associated Macrophages / immunology*
  • Tumor-Associated Macrophages / metabolism