Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer

Shashank Kumar; Kumari Sunita Prajapati; Atul Kumar Singh; Prem Prakash Kushwaha; Mohd Shuaib; Sanjay Gupta

doi:10.1016/j.canlet.2020.11.039

Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer

Cancer Lett. 2021 Apr 28:504:15-22. doi: 10.1016/j.canlet.2020.11.039. Epub 2021 Feb 6.

Authors

Shashank Kumar¹, Kumari Sunita Prajapati², Atul Kumar Singh², Prem Prakash Kushwaha², Mohd Shuaib², Sanjay Gupta³

Affiliations

¹ Department of Biochemistry, Drug Discovery and Therapeutic Laboratory, Central University of Punjab, Bathinda, 151401, India. Electronic address: shashank.kumar@cup.edu.in.
² Department of Biochemistry, Drug Discovery and Therapeutic Laboratory, Central University of Punjab, Bathinda, 151401, India.
³ Department of Urology, Case Western Reserve University, Cleveland, OH, 44106, USA; The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA; Department of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, USA; Division of General Medical Sciences, Case Comprehensive Cancer Center, Cleveland, OH, 44106, USA; Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, USA. Electronic address: sanjay.gupta@case.edu.

PMID: 33556545
DOI: 10.1016/j.canlet.2020.11.039

Abstract

The human genome transcribe an array of RNAs that do not encode proteins and may act as mediators in the regulation of gene expression. Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs consisting of more than 200 nucleotides of RNA transcripts that play important role in tumor development. Numerous lncRNAs have been characterized as functional transcripts associated with several biological processes and pathologic stages. Although the biological function and molecular mechanisms of lncRNAs remains to be explored, recent studies demonstrate aberrant expression of several lncRNAs linked with various human cancers. The present review summarizes the current knowledge of lncRNA expression patterns and mechanisms that contribute to carcinogenesis. In particular, we focus on lncRNAs regulating androgen receptor signaling pathways in prostate and breast cancer subtype having prognostic and therapeutic implications.

Keywords: Androgen receptor; Long non-coding RNAs; Prostate cancer; Signaling pathway; Triple negative breast cancer.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Breast Neoplasms / metabolism*
Female
Humans
Male
Prostatic Neoplasms / metabolism*
RNA, Long Noncoding / physiology*
Receptors, Androgen / metabolism*
Signal Transduction / physiology*

Substances

RNA, Long Noncoding
Receptors, Androgen