Circulating microparticles from subjects with active pulmonary tuberculosis infection modulate immune response

Josimar Dornelas Moreira; Fernanda Freire Campos Nunes; Fernanda Cristina Gontijo Evangelista; Henrique Rodrigues Silva; Marcela Iranda de Tonaco; Vicente de Paulo Coelho Peixoto de Toledo; Silvana Spindola de Miranda; Tânia Mara Pinto Dabés Guimarães

doi:10.1002/eji.202048844

Circulating microparticles from subjects with active pulmonary tuberculosis infection modulate immune response

Eur J Immunol. 2021 May;51(5):1282-1284. doi: 10.1002/eji.202048844. Epub 2021 Feb 26.

Authors

Josimar Dornelas Moreira^{1

2}, Fernanda Freire Campos Nunes¹, Fernanda Cristina Gontijo Evangelista¹, Henrique Rodrigues Silva¹, Marcela Iranda de Tonaco¹, Vicente de Paulo Coelho Peixoto de Toledo¹, Silvana Spindola de Miranda³, Tânia Mara Pinto Dabés Guimarães¹

Affiliations

¹ Department of Clinical and Toxicological Analysis, Pharmacy School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
² Department of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
³ Department of Medical Clinic, Medicine School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

PMID: 33554329
DOI: 10.1002/eji.202048844

Abstract

Microparticles (MPs) which circulate within the plasma are elevated in patients with active pulmonary tuberculosis infection. Circulating MPs isolated from the plasma of patients with active pulmonary tuberculosis infection modulate the cytokine production of immune cells in vitro.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Cell-Derived Microparticles / immunology
Cell-Derived Microparticles / metabolism*
Humans
Immunity
Immunomodulation*
Tuberculosis, Pulmonary / immunology*
Tuberculosis, Pulmonary / metabolism*
Tuberculosis, Pulmonary / pathology