Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier

Zhen Shi; Yazhen Wang; Tianyuan Xiao; Shaobo Dong; Tianyu Lan

doi:10.1021/acsomega.0c06075

Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier

ACS Omega. 2021 Jan 22;6(4):3427-3433. doi: 10.1021/acsomega.0c06075. eCollection 2021 Feb 2.

Authors

Zhen Shi^{1

2}, Yazhen Wang^{1

2

3}, Tianyuan Xiao², Shaobo Dong², Tianyu Lan²

Affiliations

¹ College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, Heilongjiang, China.
² Heilongjiang Provincial Key Laboratory of Polymeric Composite Materials, Qiqihar 161006, China.
³ College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, Heilongjiang, China.

Abstract

We have designed a new magnetic targeting drug carrier Fe₃O₄-PVA with a core of triiron tetroxide (Fe₃O₄) and a shell made of polyvinyl alcohol (PVA) to improve the hydrophilicity of Fe₃O₄. With adriamycin hydrochloride as a model drug, this study goes on to measure the drug carrier performance of Fe₃O₄-PVA. In addition, the thermal stability and enthalpy of thermal decomposition of Fe₃O₄-PVA were measured using a differential scanning calorimeter with a non-isothermal decomposition method. The kinetics of thermal decomposition of Fe₃O₄-PVA were also investigated. Over the course of this study, it was determined that the resulting drug carrier Fe₃O₄-PVA exhibited high drug loading levels and excellent release levels.