Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy

Riku Kawasaki; Keita Yamana; Risako Shimada; Kouta Sugikawa; Atsushi Ikeda

doi:10.1021/acsomega.0c05647

Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy

ACS Omega. 2021 Jan 19;6(4):3209-3217. doi: 10.1021/acsomega.0c05647. eCollection 2021 Feb 2.

Authors

Riku Kawasaki¹, Keita Yamana¹, Risako Shimada¹, Kouta Sugikawa¹, Atsushi Ikeda¹

Affiliation

¹ Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima 739-8527, Japan.

Abstract

With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most elegant strategies for achieving effective tumor therapy. Herein, a facile preparation and thermal process-triggered release of water-soluble photosensitizer 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (THPP) has been developed using a thermoresponsive polysaccharide, hydroxypropyl cellulose. Current systems using hydroxypropyl cellulose enable manipulation of the loading capacity of THPP into a polymer matrix and the size of the complex by varying the temperature of the solution in preparation. Furthermore, current systems have enabled the release of THPP using a heating process, mimicking the surrounding of mitochondria, and have resulted in THPP potency as a mitochondria-targeted photodynamic therapy.