Targeting evolution of antibiotic resistance by SOS response inhibition

Alexander Yakimov; Irina Bakhlanova; Dmitry Baitin

doi:10.1016/j.csbj.2021.01.003

Targeting evolution of antibiotic resistance by SOS response inhibition

Comput Struct Biotechnol J. 2021 Jan 11:19:777-783. doi: 10.1016/j.csbj.2021.01.003. eCollection 2021.

Authors

Alexander Yakimov¹, Irina Bakhlanova^{1

2}, Dmitry Baitin^{1

2}

Affiliations

¹ Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre "Kurchatov Institute", Gatchina, Russian Federation.
² Kurchatov Genome Center - PNPI, Gatchina, Russian Federation.

Abstract

Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homologous recombination involved in the processes of DNA repair should be considered as potential targets for blocking. This review highlights the current knowledge of the protein targets for the evolution of antibiotic resistance and the inhibitory effects of some new compounds on this pathway.

Keywords: Antibiotic resistance; Bacterial SOS response; RecA inhibition.

Publication types

Review