CD300a and CD300f molecules regulate the function of leukocytes

Yue Cao; Tianrang Ao; Xiaohong Wang; Wumei Wei; Jun Fan; Xiaohong Tian

doi:10.1016/j.intimp.2021.107373

CD300a and CD300f molecules regulate the function of leukocytes

Int Immunopharmacol. 2021 Apr:93:107373. doi: 10.1016/j.intimp.2021.107373. Epub 2021 Feb 4.

Authors

Yue Cao¹, Tianrang Ao², Xiaohong Wang¹, Wumei Wei¹, Jun Fan¹, Xiaohong Tian³

Affiliations

¹ Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, Liaoning 110122, China.
² Department of Cardiology, Peking Union Medical College Hospital, Tsinghua University, Beijing 100730, China.
³ Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, Liaoning 110122, China. Electronic address: xhtian@cmu.edu.cn.

PMID: 33548578
DOI: 10.1016/j.intimp.2021.107373

Abstract

The CD300 molecule family is a type I transmembrane glycoprotein expressed on cell membrane of human and other mammals, and of its eight members, only CD300a and CD300f are classified as inhibitory receptors. CD300a and CD300f play an important role in regulating the function of leukocytes, such as activation, proliferation, differentiation, migration and immunity function. They are considered as potential targets for studying the development and progression of inflammation, infection and other diseases. Here, we review the expression and regulatory mechanisms of CD300a and CD300f on leukocytes, as well as their effects on relevant diseases.

Keywords: CD300a; CD300f; Immunity; Inflammatory disease; Leukocyte.

Publication types

Review

MeSH terms

Animals
Antigens, CD / immunology*
Humans
Inflammation / immunology
Leukocytes / immunology*
Receptors, Immunologic / immunology*

Substances

Antigens, CD
CD300A protein, human
CD300LF protein, human
Receptors, Immunologic