COVID-19 infection in the palatine tonsil tissue and detritus: the detection of the virus compartment with RT-PCR

BMJ Case Rep. 2021 Feb 5;14(2):e239108. doi: 10.1136/bcr-2020-239108.

Abstract

Two patients suffering from chronic recurrent tonsillitis were reported. The first patient was confirmed infected with COVID-19, 3 weeks prior to tonsillectomy. The detritus and tonsil specimen were further analysed through real-time PCR (RT-PCR) and revealed amplification of the fragment N and ORF1ab genes of SARS-CoV-2. The second patient had a negative IgM and positive IgG antibody for COVID-19; however, the nasopharyngeal swab indicated negative for SARS-CoV-2. Tonsillectomy was performed 2 weeks after the swab; the tonsil specimen was analysed through RT-PCR and revealed amplification of the N2 and RdRp gene of SARS-CoV-2. According to both results, the presence of the SARS-CoV-2 gene remains to be detected in tonsil and/or detritus after 2-3 weeks after recovery. Hence, it is suggested that it is necessary to use adequate protection when performing tonsillectomy on early recovered patients with COVID-19. Furthermore, tonsillectomy would be more advisable to be performed after the fourth week after recovery from COVID-19.

Keywords: COVID-19; TB and other respiratory infections; ear; nose and throat/otolaryngology; otolaryngology / ENT; respiratory system.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19 / complications*
  • COVID-19 / diagnosis*
  • COVID-19 Nucleic Acid Testing / methods*
  • Female
  • Humans
  • Male
  • Palatine Tonsil / surgery
  • Palatine Tonsil / virology*
  • SARS-CoV-2
  • Tonsillectomy / methods
  • Tonsillitis / complications*
  • Tonsillitis / surgery
  • Young Adult