Benefit and danger from immunotherapy in myasthenia gravis

Neurol Sci. 2021 Apr;42(4):1367-1375. doi: 10.1007/s10072-021-05077-6. Epub 2021 Feb 5.

Abstract

In the last years, significant advances have improved the knowledge of myasthenia gravis (MG) immunopathogenesis and have enabled to realize new molecules with a selective action targeting compounds of the immunological system. This review discusses emerging treatments for MG, including complement inhibitors, neonatal Fc receptor targeting agents, and B cell interfering drugs, focusing on benefit and danger. In the second section of the review, several related adverse events of immunotherapy, including MGonset, are debated.

Keywords: Checkpoint inhibitors; Emerging therapy; Immunotherapy; Refractory myasthenia gravis.

Publication types

  • Review

MeSH terms

  • B-Lymphocytes
  • Humans
  • Immunologic Factors
  • Immunotherapy / adverse effects
  • Infant, Newborn
  • Myasthenia Gravis* / therapy

Substances

  • Immunologic Factors