5-HT/GABA interaction in neurodevelopment and plasticity

Gabriele Deidda; Massimo Pierucci; Vincenzo Crunelli; Giuseppe Di Giovanni

doi:10.1016/bs.pbr.2021.01.009

5-HT/GABA interaction in neurodevelopment and plasticity

Prog Brain Res. 2021:259:287-317. doi: 10.1016/bs.pbr.2021.01.009. Epub 2021 Jan 22.

Authors

Gabriele Deidda¹, Massimo Pierucci², Vincenzo Crunelli³, Giuseppe Di Giovanni³

Affiliations

¹ Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. Electronic address: gabrieledeidda@hotmail.it.
² Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
³ Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom.

PMID: 33541680
DOI: 10.1016/bs.pbr.2021.01.009

Abstract

The adult brain is the result of a multistages complex neurodevelopmental process involving genetic, molecular and microenvironmental factors as well as diverse patterns of electrical activity. In the postnatal life, immature neuronal circuits undergo an experience-dependent maturation during critical periods of plasticity, but the brain still retains plasticity during adult life. In all these stages, the neurotransmitter GABA plays a pivotal role. In this chapter, we will describe the interaction of 5-HT with GABA in regulating neurodevelopment and plasticity.

Keywords: 5-HT; Adult neurogenesis; Critical period; GABA; Neurodevelopment; Plasticity; Somatosensory cortex; Visual cortex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Critical Period, Psychological
Neuronal Plasticity
Serotonin
Visual Cortex*
gamma-Aminobutyric Acid

Substances

Serotonin
gamma-Aminobutyric Acid