Chronic Thromboembolic Disease and Chronic Thromboembolic Pulmonary Hypertension

Irene M Lang; Ioana A Campean; Roela Sadushi-Kolici; Roza Badr-Eslam; Christian Gerges; Nika Skoro-Sajer

doi:10.1016/j.ccm.2020.11.014

Chronic Thromboembolic Disease and Chronic Thromboembolic Pulmonary Hypertension

Clin Chest Med. 2021 Mar;42(1):81-90. doi: 10.1016/j.ccm.2020.11.014. Epub 2021 Jan 12.

Authors

Irene M Lang¹, Ioana A Campean², Roela Sadushi-Kolici², Roza Badr-Eslam², Christian Gerges², Nika Skoro-Sajer²

Affiliations

¹ Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria. Electronic address: irene.lang@meduniwien.ac.at.
² Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria.

PMID: 33541619
DOI: 10.1016/j.ccm.2020.11.014

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic pulmonary vascular disease (CTED) are rare manifestations of venous thromboembolism. Presumably, CTEPH and CTED are variants of the same pathophysiological mechanism. CTEPH and CTED can be near-cured by pulmonary endarterectomy, balloon pulmonary angioplasty, and medical treatment with Riociguat or subcutaneous treprostinil, which are the approved drugs.

Keywords: Acute pulmonary embolism; Chronic thromboembolic pulmonary hypertension; Chronic thromboembolic pulmonary vascular disease; Venous thromboembolism.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chronic Disease / therapy
Humans
Hypertension, Pulmonary* / etiology
Hypertension, Pulmonary* / physiopathology
Hypertension, Pulmonary* / therapy
Pulmonary Embolism* / etiology
Pulmonary Embolism* / physiopathology
Pulmonary Embolism* / therapy
Venous Thromboembolism / complications*