PprI: The Key Protein in Response to DNA Damage in Deinococcus

Huizhi Lu; Yuejin Hua

doi:10.3389/fcell.2020.609714

PprI: The Key Protein in Response to DNA Damage in Deinococcus

Front Cell Dev Biol. 2021 Jan 18:8:609714. doi: 10.3389/fcell.2020.609714. eCollection 2020.

Authors

Huizhi Lu¹, Yuejin Hua¹

Affiliation

¹ MOE Key Laboratory of Biosystems Homeostasis and Protection, Institute of Biophysics, College of Life Sciences, Zhejiang University, Hangzhou, China.

Abstract

Deoxyribonucleic acid (DNA) damage response (DDR) pathways are essential for maintaining the integrity of the genome when destabilized by various damaging events, such as ionizing radiation, ultraviolet light, chemical or oxidative stress, and DNA replication errors. The PprI-DdrO system is a newly identified pathway responsible for the DNA damage response in Deinococcus, in which PprI (also called IrrE) acts as a crucial component mediating the extreme resistance of these bacteria. This review describes studies about PprI sequence conservation, regulatory function, structural characteristics, biochemical activity, and hypothetical activation mechanisms as well as potential applications.

Keywords: DNA damage response; Deinococcus; PprI; PprI-DdrO system; switch.

Publication types

Review