Molecular Mechanisms of Diaphragm Myopathy in Humans With Severe Heart Failure

Circ Res. 2021 Mar 19;128(6):706-719. doi: 10.1161/CIRCRESAHA.120.318060. Epub 2021 Feb 4.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT02663115.

Keywords: diaphragm; heart failure; mitochondria; mitophagy; reactive oxygen species.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / metabolism
  • Diaphragm / metabolism*
  • Diaphragm / physiopathology
  • Diaphragm / ultrastructure
  • Female
  • Heart Failure / complications
  • Heart Failure / metabolism*
  • Heart Failure / pathology
  • Humans
  • Male
  • Middle Aged
  • Mitochondria, Muscle / metabolism*
  • Mitochondria, Muscle / ultrastructure
  • Muscle Proteins / metabolism
  • Muscle Weakness / etiology
  • Muscle Weakness / metabolism*
  • Muscle Weakness / pathology
  • NADPH Oxidases / metabolism
  • Ryanodine Receptor Calcium Release Channel / metabolism
  • Tripartite Motif Proteins / metabolism
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Muscle Proteins
  • RYR1 protein, human
  • Ryanodine Receptor Calcium Release Channel
  • Tripartite Motif Proteins
  • NADPH Oxidases
  • TRIM63 protein, human
  • Ubiquitin-Protein Ligases
  • Calcium

Associated data

  • ClinicalTrials.gov/NCT02663115