The host glycomic response to pathogens

Rui Qin; Lara K Mahal

doi:10.1016/j.sbi.2020.12.011

The host glycomic response to pathogens

Curr Opin Struct Biol. 2021 Jun:68:149-156. doi: 10.1016/j.sbi.2020.12.011. Epub 2021 Jan 30.

Authors

Rui Qin¹, Lara K Mahal²

Affiliations

¹ Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada.
² Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada. Electronic address: lkmahal@ualberta.ca.

PMID: 33529786
DOI: 10.1016/j.sbi.2020.12.011

Abstract

Glycans play important roles in the biology of infectious diseases. Although glycans are expressed on both the pathogens and the host, the functions and dynamics of the host glycome during infection are not well understood. Recent years have witnessed new discoveries on the host glycome respsonse to infection, as well as related mechanisms and their implications. Herein, we present a brief review on the latest findings in this field and put them in the context of host immunity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Glycomics*
Polysaccharides*

Substances

Polysaccharides