Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.
在发达国家，上皮性卵巢癌仍然是最致命的妇科肿瘤，研发新的卵巢癌治疗策略对战胜这一疾病具有重要意义。根据组织、 分子和遗传差异，上皮性卵巢癌可分为多种亚型。在研发新的卵巢癌治疗策略的研究中，使用临床疾病相关的临床前动物模型对转化相关研究成果至关重要。我们总结了相关卵巢癌临床前小鼠模型的新进展并探讨了不同小鼠模型的优缺点。.
Keywords: Epithelial ovarian cancer; Genetic engineered mouse model; Intraperitoneal mouse model; Orthotopic mouse model; Patient-derived xenografts; Subcutaneous mouse model; Syngeneic mouse model.