Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes

J Lacy Kamm; Christopher B Riley; Natalie Parlane; Erica K Gee; C Wayne McIlwraith

doi:10.3389/fvets.2020.617647

Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes

Front Vet Sci. 2021 Jan 13:7:617647. doi: 10.3389/fvets.2020.617647. eCollection 2020.

Authors

J Lacy Kamm¹, Christopher B Riley¹, Natalie Parlane², Erica K Gee¹, C Wayne McIlwraith³

Affiliations

¹ School of Veterinary Science, Massey University, Palmerston North, New Zealand.
² Hopkirk Laboratory, AgResearch, Palmerston North, New Zealand.
³ Orthopaedic Research Center, C. Wayne McIlwraith Translational Medical Institute, Colorado State University, Fort Collins, CO, United States.

Abstract

Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign cells, and later, the adaptive immune system, a delayed response that causes cell death due to recognition of specific alloantigens by host cells and antibodies. This review describes the actions of MSCs to both suppress and activate the different arms of the immune system. We then review the survival and effectiveness of the currently used allogeneic MSC treatments.

Keywords: allogeneic; equine; immune; lymphocyte; mesenchymal stromal cell.

Publication types

Review