Progress in Research on SARS-CoV-2 Infection Causing Neurological Diseases and Its Infection Mechanism

Lintao Wang; Zhiguang Ren; Li Ma; Yanjie Han; Wenqiang Wei; Enshe Jiang; Xin-Ying Ji

doi:10.3389/fneur.2020.592888

Progress in Research on SARS-CoV-2 Infection Causing Neurological Diseases and Its Infection Mechanism

Front Neurol. 2021 Jan 13:11:592888. doi: 10.3389/fneur.2020.592888. eCollection 2020.

Authors

Lintao Wang^{1

2}, Zhiguang Ren^{2

3}, Li Ma^{2

4}, Yanjie Han^{2

5}, Wenqiang Wei^{2

3}, Enshe Jiang^{2

6}, Xin-Ying Ji²

Affiliations

¹ School of Clinical Medicine, Henan University, Kaifeng, China.
² Henan International Joint Laboratory for Nuclear Protein Regulation and Kaifeng Key Laboratory of Infectious Diseases and Bio-safety, Henan University, Kaifeng, China.
³ School of Basic Medical Sciences, Henan University, Kaifeng, China.
⁴ Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
⁵ Clinical Laboratory, Functional Laboratory, Respiratory Department, Kaifeng Central Hospital, Kaifeng, China.
⁶ Institute of Nursing and Health, School of Nursing and Health, Henan University, Kaifeng, China.

Abstract

COVID-19 has spread rapidly worldwide since its outbreak and has now become a major public health problem. More and more evidence indicates that SARS-CoV-2 may not only affect the respiratory system but also cause great harm to the central nervous system. Therefore, it is extremely important to explore in-depth the impact of SARS-CoV-2 infection on the nervous system. In this paper, the possible mechanisms of SARS-CoV-2 invading the central nervous system during COVID-19, and the neurological complications caused by SARS-CoV-2 infection were reviewed.

Keywords: ACE2; COVID-19; SARS-CoV-2; central nervous system; neurological complications; olfactorial nerve.

Publication types

Review