Prognostic Influence of Cytoplasmic/Nuclear Hepatoma-derived Growth Factor in Head and Neck Cancer

Anticancer Res. 2021 Feb;41(2):803-810. doi: 10.21873/anticanres.14832.

Abstract

Background/aim: We investigated the prognostic influence of both hepatoma-derived growth factor (HDGF) and p53 expression in head and neck cancer.

Materials and methods: HDGF and p53 immunostaining was scored based on staining intensities and percentage of tumor cells stained using tissue microarray composed of total 102 head and neck cancer samples.

Results: Over-expression of HDGF and p53 was observed in cancer compared with adjacent normal tissues (p<0.001). In multivariate analyses, tumors with higher nuclear and cytoplasmic HDGF staining scores (p=0.019), and tumors with cN1-cN2 (compared with cN0) (p=0.014), were associated with worse overall survival.

Conclusion: The increased expression of HDGF and p53 in the tumor compared with adjacent normal tissues could be a risk factor for tumorigenesis. Increased nuclear and cytoplasmic expression of HDGF, and cN staging correlated with overall survival and negatively influenced prognosis in head and neck cancer.

Keywords: Cytoplasmic/nuclear HDGF; head and neck cancer; p53; prognosis.

MeSH terms

  • Aged
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic
  • Head and Neck Neoplasms / metabolism
  • Head and Neck Neoplasms / mortality
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Survival Analysis
  • Tissue Array Analysis
  • Tumor Suppressor Protein p53 / metabolism*
  • Up-Regulation*

Substances

  • Intercellular Signaling Peptides and Proteins
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • hepatoma-derived growth factor