Adapting to supply-and-demand emerging trends for antigen-negative red blood cell units

Transfusion. 2021 May;61(5):1489-1494. doi: 10.1111/trf.16285. Epub 2021 Jan 29.

Abstract

Background: A global downtrend in blood usage has been observed by many countries, while the demand for antigen-negative red blood cell (RBC) units used in antigen-matched transfusions keeps increasing. The declining number of units collected exposes blood providers to a rapidly evolving supply challenge.

Methods: This study was conducted retrospectively with use of internal data analysis to weigh Québec's situation regarding global and antigen-negative RBC demand, to measure the effects of community-directed recruitment and blood drives, and to evaluate the benefits of mass-scale RBC genotyping.

Results: Our findings confirm a global RBC usage downtrend of over 20% total in the past 10 years with a steady antigen-negative usage and highlight the most requested negative antigen combinations. Our data also show our +39.5% progress regarding the number of Black donors recruited for antigen matching of patients with sickle cell disease in the past 3 years, as well as a constantly growing number of just-in-time blood collection for complex orders. Finally, our data summarize the efficiency of our mass-scale RBC genotyping efforts.

Conclusion: Altogether, this study confirms the demand trends for regular and antigen-negative RBC units in Québec and the efficient effects of our recruitment and typing strategies.

Keywords: blood center operations; blood management; donors.

MeSH terms

  • Blood Group Antigens / blood*
  • Blood Grouping and Crossmatching
  • Donor Selection* / methods
  • Erythrocyte Transfusion* / methods
  • Humans
  • Retrospective Studies
  • Tissue Donors

Substances

  • Blood Group Antigens