Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering

Xinming Gu; Xiaolin Sun; Yue Sun; Jia Wang; Yiping Liu; Kaixuan Yu; Yao Wang; Yanmin Zhou

doi:10.3389/fbioe.2020.631616

Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering

Front Bioeng Biotechnol. 2021 Jan 12:8:631616. doi: 10.3389/fbioe.2020.631616. eCollection 2020.

Authors

Xinming Gu¹, Xiaolin Sun¹, Yue Sun¹, Jia Wang¹, Yiping Liu¹, Kaixuan Yu¹, Yao Wang¹, Yanmin Zhou¹

Affiliation

¹ Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, China.

Abstract

In recent years, polyetheretherketone (PEEK) has been increasingly employed as an implant material in clinical applications. Although PEEK is biocompatible, chemically stable, and radiolucent and has an elastic modulus similar to that of natural bone, it suffers from poor integration with surrounding bone tissue after implantation. To improve the bioactivity of PEEK, numerous strategies for functionalizing the PEEK surface and changing the PEEK structure have been proposed. Inspired by the components, structure, and function of bone tissue, this review discusses strategies to enhance the biocompatibility of PEEK implants and provides direction for fabricating multifunctional implants in the future.

Keywords: bioactivity; implants; osseointegration; polyetheretherketone; surface modification.

Publication types

Review