BAF Complex in Embryonic Stem Cells and Early Embryonic Development

Heyao Zhang; Xuepeng Wang; Jingsheng Li; Ronghua Shi; Ying Ye

doi:10.1155/2021/6668866

BAF Complex in Embryonic Stem Cells and Early Embryonic Development

Stem Cells Int. 2021 Jan 16:2021:6668866. doi: 10.1155/2021/6668866. eCollection 2021.

Authors

Heyao Zhang¹, Xuepeng Wang², Jingsheng Li¹, Ronghua Shi³, Ying Ye¹

Affiliations

¹ Cam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou, Jiangsu 215000, China.
² College of Traditional Chinese Medicine, Macau University of Science and Technology, China.
³ School of Life Sciences, University of Science and Technology of China, China.

Abstract

Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes. In this review, we summarize the research progresses of the functional and mechanistic studies of BAF complex in mouse ESCs and early embryonic development. A discussion of the mechanistic bases underlying the distinct phenotypes upon the deletion of different BAF subunits in ESCs and embryos will be highlighted.

Publication types

Review