Correlation of Anti-Mullerian Hormone Level and Antral Follicle Count with Oocyte Number in A Fixed-Dose Controlled Ovarian Hyperstimulation of Patients of In Vitro Fertilization Program

Wiryawan Permadi; Mohammad Wahyu Ferdian; Dian Tjahyadi; Wulan Ardhana Iswari; Tono Djuwantono

doi:10.22074/ijfs.2021.6238

Correlation of Anti-Mullerian Hormone Level and Antral Follicle Count with Oocyte Number in A Fixed-Dose Controlled Ovarian Hyperstimulation of Patients of In Vitro Fertilization Program

Int J Fertil Steril. 2021 Jan;15(1):40-43. doi: 10.22074/ijfs.2021.6238. Epub 2021 Jan 19.

Authors

Wiryawan Permadi¹, Mohammad Wahyu Ferdian², Dian Tjahyadi², Wulan Ardhana Iswari², Tono Djuwantono²

Affiliations

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital (RSHS), Bandung, Indonesia. Email: wiryawan_permadi@yahoo.com.
² Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin Hospital (RSHS), Bandung, Indonesia.

Abstract

Background: This study was conducted to determine the correlation of anti-Mullerian hormone (AMH) level and antral follicle count (AFC) with oocyte count in women who had received controlled ovarian hyperstimulation in an in vitro fertilization (IVF) program.

Materials and methods: We retrospectively gathered the data of 42 patients who underwent IVF during 2005-2017 at Aster Clinic in Dr. Hasan Sadikin Hospital and Bandung Fertility Center Limijati Hospital, Indonesia. Details of the subjects such as identity, characteristics, history of illness, history of previous therapy, levels of ovarian reserve markers examined (AFC and AMH), follicle-stimulating hormone (FSH) dose given, and number of oocytes produced were recorded.

Results: A significant positive correlation between AMH (P≤0.001, r=0.530), AFC (P≤0.001, r=0.687), and AMHAFC combination (P≤0.001, r=0.652), and the number of oocytes was found at the FSH dose of 225 IU.

Conclusion: AFC and AMH are able to reliably predict ovarian response to FSH.

Keywords: Anti-Mullerian Hormone; In Vitro Fertilization; Ovarian Response.