Human olfactory dysfunction: causes and consequences

Cell Tissue Res. 2021 Jan;383(1):569-579. doi: 10.1007/s00441-020-03381-9. Epub 2021 Jan 26.

Abstract

The sense of smell essentially contributes to social communication, guides nutrition behaviour and elicits avoidance towards environmental hazards. Olfactory smell impairment may hence entail severe consequences for affected individuals. Compared with sensory loss in other modalities, reduced olfactory function is often unnoticed by those affected and diagnosed late. Those patients seeking help frequently suffer from long-term impairments resulting in reduced well-being and quality of life. The current review provides an overview of aetiology, prevalence and specifics of diagnostics in acquired and congenital olfactory loss and focusses on short- and long-term consequences. Compensation strategies are elaborated, and treatment options are mentioned. Individual characteristics associated with the development of serious mental health impairment are discussed in order to help practitioners identifying populations at risk.

Keywords: Olfactory impairment; Serious mental health impairment; Short- and long-term consequences.

Publication types

  • Review

MeSH terms

  • Humans
  • Olfaction Disorders / diagnosis*
  • Olfaction Disorders / etiology*
  • Olfaction Disorders / therapy*