CXCR5-CXCL13 axis markers in full-term and preterm human neonates in the first weeks of life

Eur J Immunol. 2021 May;51(5):1289-1292. doi: 10.1002/eji.202048831. Epub 2021 Feb 9.

Abstract

Term and preterm neonates have very few circulating Tfh-like cells (cTfh), and no circulating Tfr-like cells. Neonatal cTfh are CXCR5lo PD-1lo CD45RAhi , suggestive of a naive, possibly recently activated phenotype. CXCL13 is high at birth, but decreases rapidly in the first weeks of life. Overall, signs of GC activity in human neonates are weak, even in those born prematurely or after sepsis.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers*
  • Chemokine CXCL13 / metabolism*
  • Disease Susceptibility
  • Humans
  • Immunophenotyping
  • Infant, Newborn
  • Premature Birth / metabolism*
  • Receptors, CXCR5 / metabolism*
  • T-Lymphocytes, Helper-Inducer / immunology
  • T-Lymphocytes, Helper-Inducer / metabolism
  • Term Birth / metabolism*

Substances

  • Biomarkers
  • CXCL13 protein, human
  • CXCR5 protein, human
  • Chemokine CXCL13
  • Receptors, CXCR5