Prediction of Response in Head and Neck Tumor: Focus on Main Hot Topics in Research

Liliana Belgioia; Silvia Daniela Morbelli; Renzo Corvò

doi:10.3389/fonc.2020.604965

Prediction of Response in Head and Neck Tumor: Focus on Main Hot Topics in Research

Front Oncol. 2021 Jan 8:10:604965. doi: 10.3389/fonc.2020.604965. eCollection 2020.

Authors

Liliana Belgioia^{1

2}, Silvia Daniela Morbelli^{2

3}, Renzo Corvò^{1

2}

Affiliations

¹ Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
² Health Science Department (DISSAL), University of Genoa, Genoa, Italy.
³ Nuclear Medicine Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Abstract

Radiation therapy is a cornerstone in the treatment of head and neck cancer patients; actually, their management is based on clinical and radiological staging with all patients at the same stage treated in the same way. Recently the increasing knowledge in molecular characterization of head and neck cancer opens the way for a more tailored treatment. Patient outcomes could be improved by a personalized radiotherapy beyond technological and anatomical precision. Several tumor markers are under evaluation to understand their possible prognostic or predictive value. In this paper we discuss those markers specific for evaluate response to radiation therapy in head and neck cancer for a shift toward a biological personalization of radiotherapy.

Keywords: biomarkers; head and neck cancer; precision medicine; predictive factors; prognostic factors; radiation therapy.

Publication types

Review