Hidradenitis Suppurativa Associated with Galli-Galli Disease: Extending the Link with Dowling-Degos Disease

María Del Mar; Meléndez González; Christopher Sayed; Pushkar Phadke

Hidradenitis Suppurativa Associated with Galli-Galli Disease: Extending the Link with Dowling-Degos Disease

J Clin Aesthet Dermatol. 2020 Dec;13(12):38-40. Epub 2020 Dec 1.

Authors

María Del Mar^{1

2

3}, Meléndez González^{1

2

3}, Christopher Sayed^{1

2

3}, Pushkar Phadke^{1

2

3}

Affiliations

¹ Ms. Meléndez González is with the Universidad Central del Caribe School of Medicine in Bayamon, Puerto Rico.
² Dr. Sayed is with the Department of Dermatology at the University of North Carolina School of Medicine in Chapel Hill, North Carolina.
³ Dr. Phadke is with Dermpath Diagnostics South Florida in Pompano Beach, Florida.

PMID: 33488918
PMCID: PMC7819595

Abstract

Galli-Galli disease (GGD) is a rare genodermatosis that is distinguished from Dowling-Degos disease (DDD) by the histologic finding of acantholysis. We present a case of a female patient with pruritic intertriginous plaques and history of hidradenitis suppurativa (HS). While reports exist associating DDD with HS, to our knowledge, GGD in association with HS has not been reported in recent literature. HS in association with DDD has been found to have causal mutations, involving the gamma-secretase complex and POFUT1 genes. DDD also has shared causal mutations with GGD in the POGLUT1 and KRT5 genes. These three skin diseases have been linked to different gene mutations, which are all associated with the Notch signaling pathway.

Keywords: Comorbidity; Dowling-Degos disease (DDD); Galli-Galli disease (GGD); genetics, hidradenitis suppurativa (HS); hyperpigmentation.

Publication types

Review