Bacterial cellulose-based re-swellable hydrogel: Facile preparation and its potential application as colorimetric sensor of sweat pH and glucose

Tatiya Siripongpreda; Benjawan Somchob; Nadnudda Rodthongkum; Voravee P Hoven

doi:10.1016/j.carbpol.2020.117506

Bacterial cellulose-based re-swellable hydrogel: Facile preparation and its potential application as colorimetric sensor of sweat pH and glucose

Carbohydr Polym. 2021 Mar 15:256:117506. doi: 10.1016/j.carbpol.2020.117506. Epub 2020 Dec 13.

Authors

Tatiya Siripongpreda¹, Benjawan Somchob², Nadnudda Rodthongkum³, Voravee P Hoven⁴

Affiliations

¹ Nanoscience and Technology Interdisciplinary Program, Chulalongkorn University, Phayathai Road, Wangmai, Pathumwan, Bangkok, 10330, Thailand.
² Program in Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University, Phayathai Road, Wangmai, Pathumwan, Bangkok, 10330, Thailand.
³ Metallurgy and Materials Science Research Institute, Chulalongkorn University, Phayathai Road, Wangmai, Pathumwan, Bangkok, 10330, Thailand; Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: Nadnudda.R@chula.ac.th.
⁴ Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand; Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Wangmai, Pathumwan, Bangkok, 10330, Thailand; Center of Excellence in Materials and Biointerfaces, Chulalongkorn University, Phayathai Road, Wangmai, Pathumwan, Bangkok, 10330, Thailand. Electronic address: Vipavee.P@chula.ac.th.

PMID: 33483028
DOI: 10.1016/j.carbpol.2020.117506

Abstract

Direct deposition of the negatively charged polyelectrolyte, carboxymethyl cellulose (CMC), into a bacterial cellulose (BC) matrix was used as a simple route to fabricate a re-swellable and biocompatible cellulose-based hydrogel. As a result of this non-destructive approach, the physical and mechanical property of the original BC were well-preserved within the resulting BC/CMC hydrogel. As a BC/CMC-based colorimetric pH sensor, it exhibited a rapid response with an easy color differentiation between each pH by the naked eye, and wide linear range of pH 4.0-9.0 with good linearity. For the detection of glucose in sweat, the BC/CMC-based colorimetric glucose sensor provided a low limit of detection (25 μM) with a wide linear detection range (0.0-0.5 mM) and high accuracy. These BC/CMC based sensors could potentially be applied as non-invasive semi-quantitative sensors for on-skin health monitoring.

Keywords: Biocompatible hydrogel; Carboxymethyl cellulose; Non-invasive sensor; Semi-double network.

MeSH terms

Biosensing Techniques*
Carboxymethylcellulose Sodium / chemistry
Cellulose / chemistry*
Color
Colorimetry / methods*
Gluconacetobacter xylinus / chemistry*
Glucose / analysis*
Humans
Hydrogels
Hydrogen-Ion Concentration
Limit of Detection
Static Electricity
Sweat / chemistry*
Water / chemistry
Wettability

Substances

Hydrogels
Water
Cellulose
Glucose
Carboxymethylcellulose Sodium