Contributions of exopolysaccharides from lactic acid bacteria as biotechnological tools in food, pharmaceutical, and medical applications

Int J Biol Macromol. 2021 Mar 15:173:79-89. doi: 10.1016/j.ijbiomac.2021.01.110. Epub 2021 Jan 19.

Abstract

Exopolysaccharides (EPS) are important bioproducts produced by some genera of lactic acid bacteria. EPS are famous for their shelf-life improving properties, techno-functional enhancing abilities in food and dairy industries, besides their beneficial health effects. Furthermore, exopolysaccharides have many prospective and well-established contributions in the field of drugs and diagnostic industry. In this review, classification of EPS produced by LAB was presented. Moreover, current and potential applications of EPS in food, dairy, baking industries, cereal-based, and functional products were described. Also, some clinical and pharmaceutical applications of EPS such as intelligent drug delivery systems (microsystems and nanosystems for sustained delivery), interpenetrating polymer networks (IPNs), anticancer drug-targeting, recombinant macromolecular biopharmaceuticals, gene delivery, tissue engineering, and role of EPS in diagnostics were highlighted. Finally, future prospects concerning enhancing EPS production, minimizing costs of their production, and exploring their contribution in further applications were discussed.

Keywords: Applications; Biotechnology; Exopolysaccharides; Food; Lactic acid bacteria; Pharmaceuticals.

Publication types

  • Review

MeSH terms

  • Anticholesteremic Agents / isolation & purification
  • Anticholesteremic Agents / therapeutic use*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / therapeutic use*
  • Antioxidants / isolation & purification
  • Antioxidants / therapeutic use*
  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / isolation & purification
  • Delayed-Action Preparations / therapeutic use*
  • Fermented Foods / microbiology
  • Food Technology / methods
  • Gene Transfer Techniques
  • Humans
  • Lactobacillaceae / chemistry
  • Lactobacillaceae / metabolism
  • Polysaccharides, Bacterial / isolation & purification
  • Polysaccharides, Bacterial / therapeutic use*
  • Probiotics / isolation & purification
  • Probiotics / therapeutic use*
  • Tissue Engineering / methods

Substances

  • Anticholesteremic Agents
  • Antineoplastic Agents
  • Antioxidants
  • Delayed-Action Preparations
  • Polysaccharides, Bacterial