Complete Genome Sequence of Mycobacterium bovis BCG SL222 Sofia, the First WHO Reference Reagent for the M. bovis BCG Vaccine of the Russian BCG-I Substrain

Stefan Panaiotov; Yordan Hodzhev; Vladimir Tolchkov; Alexander Mihailov; Roumen Kofinov; Todor Kantardjiev; Tzvetelina Stefanova

doi:10.1128/MRA.01318-20

Complete Genome Sequence of Mycobacterium bovis BCG SL222 Sofia, the First WHO Reference Reagent for the M. bovis BCG Vaccine of the Russian BCG-I Substrain

Microbiol Resour Announc. 2021 Jan 21;10(3):e01318-20. doi: 10.1128/MRA.01318-20.

Authors

Stefan Panaiotov¹, Yordan Hodzhev², Vladimir Tolchkov², Alexander Mihailov³, Roumen Kofinov³, Todor Kantardjiev², Tzvetelina Stefanova³

Affiliations

¹ National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria spanaiotov@yahoo.com.
² National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
³ BB-NCIPD Ltd., Sofia, Bulgaria.

Abstract

Mycobacterium bovis BCG SL222 Sofia is a substrain descending from the Russian BCG-I vaccine strain. Here, we report the complete genome sequence of BCG SL222 Sofia, which will facilitate identity assurance and will contribute to more consistent manufacturing, standardization, and differentiation of substrains used in vaccine production.