Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

Alberto Cagigi; Karin Loré

doi:10.3390/vaccines9010061

Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

Vaccines (Basel). 2021 Jan 18;9(1):61. doi: 10.3390/vaccines9010061.

Authors

Alberto Cagigi¹, Karin Loré¹

Affiliation

¹ Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 161 64 Solna, Sweden.

Abstract

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.

Keywords: SARS-CoV-2; Th1 polarization; antibody response; dendritic cell; mRNA vaccine; protein translation; type I interferon.

Publication types

Review

Abstract

Publication types

Grants and funding