Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate

Abstract

Mitochondrial quality control is crucial for sustaining cellular maintenance. Mitochondrial Ca²⁺ plays an important role in the maintenance of mitochondrial quality control through regulation of mitochondrial dynamics, mitophagy and mitochondrial biogenesis for preserving cellular homeostasis. The regulation of this dynamic interlink between these mitochondrial networks and mitochondrial Ca²⁺ appears indispensable for the adaptation of cells under external stimuli. Moreover, dysregulation of mitochondrial Ca²⁺ divulges impaired mitochondrial control that results in several pathological conditions such as cancer. Hence this review untangles the interplay between mitochondrial Ca²⁺ and quality control that govern mitochondrial health and mitochondrial coordinates in the development of cancer.

Keywords: Cancer; Mitochondrial Ca(2+); Mitochondrial biogenesis; Mitochondrial quality control; Mitophagy.