Functions of nuclear receptors SUMOylation

Wenhui Liu; Min Zeng; Nian Fu

doi:10.1016/j.cca.2021.01.007

Functions of nuclear receptors SUMOylation

Clin Chim Acta. 2021 May:516:27-33. doi: 10.1016/j.cca.2021.01.007. Epub 2021 Jan 18.

Authors

Wenhui Liu¹, Min Zeng¹, Nian Fu²

Affiliations

¹ Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China; Liver Disease Laboratory, Clinical Research Institute, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
² Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China; Liver Disease Laboratory, Clinical Research Institute, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China. Electronic address: 2002funian@163.com.

PMID: 33476589
DOI: 10.1016/j.cca.2021.01.007

Abstract

The nuclear receptor superfamily is a family of ligand-activated transcription factors that play a key role in cell metabolism and human diseases. They can be modified after translation, such as acetylation, ubiquitination, phosphorylation and SUMOylation. Crosstalk between SUMO and ubiquitin, phosphorylation and acetylation regulates a variety of metabolic and physiological activities. Nuclear receptors play an important role in lipid metabolism, inflammation, bile acid homeostasis and autophagy. SUMOylation nuclear receptors can regulate their function and affect cell metabolism. It also provides a potential therapeutic target for atherosclerosis, tumor and other metabolic and inflammation-related diseases. This review focuses on the function of SUMOylation nuclear receptors.

Keywords: Crosstalk; Nuclear receptors; SUMO; SUMOylation.

Publication types

Review

MeSH terms

Humans
Protein Processing, Post-Translational
Receptors, Cytoplasmic and Nuclear*
Sumoylation*
Transcription Factors / metabolism
Ubiquitination

Substances

Receptors, Cytoplasmic and Nuclear
Transcription Factors