Management of Severe and Severe/Complicated Clostridoides difficile Infection Using Sequential Fecal Microbiota Transplant by Retention Enema

Abbas Hatim Rupawala; Darrel Gachette; Mena Bakhit; Lanre Jimoh; Colleen R Kelly

doi:10.1093/cid/ciab041

Management of Severe and Severe/Complicated Clostridoides difficile Infection Using Sequential Fecal Microbiota Transplant by Retention Enema

Clin Infect Dis. 2021 Aug 16;73(4):716-719. doi: 10.1093/cid/ciab041.

Authors

Abbas Hatim Rupawala¹, Darrel Gachette², Mena Bakhit³, Lanre Jimoh⁴, Colleen R Kelly¹

Affiliations

¹ Division of Gastroenterology, Department of Internal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
² Department of Internal Medicine, NYU Langone Medical Center, New York, New York, USA.
³ Division of Gastroenterology, Lahey Clinic, Burlington, Massachusetts, USA.
⁴ Carolina Digestive, Charlotte, North Carolina, USA.

PMID: 33476379
DOI: 10.1093/cid/ciab041

Abstract

We evaluated serial fecal microbiota transplant (FMT) by retention enema in patients with severe or severe/complicated Clostridoides difficile infection (CDI) unresponsive to at least 48 hours of standard antibiotic therapy. Of the 15 patients included, despite initial improvement in most patients, only 5 patients sustained cure at 30 days, and serious adverse events occurred in 4 patients.

Keywords: FMT; complicated C. difficile infection; enema; fecal microbiota transplant; severe C. difficile infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Clostridioides difficile*
Clostridium Infections* / therapy
Enema
Fecal Microbiota Transplantation
Feces
Humans
Microbiota*
Recurrence
Treatment Outcome