C1 Esterase Inhibition: Targeting Multiple Systems in COVID-19

J Clin Immunol. 2021 May;41(4):729-732. doi: 10.1007/s10875-021-00972-1. Epub 2021 Jan 21.

Authors

T M Ayodele Adesanya¹, Courtney M Campbell², Lijun Cheng³, Princess U Ogbogu⁴, Rami Kahwash²

Affiliations

¹ Department of Family and Community Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. timothy.adesanya@osumc.edu.
² Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
³ Department of Biomedical Informatics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
⁴ Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, USA.

No abstract available

Publication types

Letter
Review

MeSH terms

Blood Coagulation / drug effects
Blood Coagulation / immunology
COVID-19 / blood
COVID-19 / immunology*
COVID-19 / virology
COVID-19 Drug Treatment
Complement Activation / drug effects
Complement Activation / immunology
Complement C1 Inhibitor Protein / metabolism*
Complement C1s / antagonists & inhibitors*
Complement C1s / metabolism
Complement Inactivating Agents / pharmacology
Complement Inactivating Agents / therapeutic use
Humans
Immunity, Innate / drug effects
SARS-CoV-2 / immunology*
SARS-CoV-2 / metabolism
Thrombosis / blood
Thrombosis / immunology*
Thrombosis / prevention & control

Substances

Complement C1 Inhibitor Protein
Complement Inactivating Agents
Complement C1s