Unusual presentation of cis-platinum neuropathy

Neurology. 1988 Mar;38(3):488-90. doi: 10.1212/wnl.38.3.488.

Abstract

Symptoms and signs of cis-diamminedichloroplatinum II (DDP) neuropathy usually develop during treatment and stabilize or improve when DDP is stopped. We report three patients whose symptoms began 3 to 8 weeks after the last dose of DDP and progressed over 1 or 2 months to moderate-marked disability. The clinical picture in each was consistent with DDP neuropathy, and no other cause could be identified. Two of the patients improved over 8 and 27 months to become asymptomatic; the other died 2 months after presentation. It is important to recognize that DDP neuropathy can present after treatment has been discontinued since the clinical picture mimics the paraneoplastic dorsal root ganglionitis, which has a different prognosis.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects*
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Foot
  • Hand
  • Humans
  • Leg
  • Middle Aged
  • Nervous System Diseases / chemically induced*
  • Sensation / drug effects
  • Uterine Neoplasms / drug therapy
  • Uterine Neoplasms / secondary

Substances

  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin