Quaternary Lidocaine Derivatives: Past, Present, and Future

Drug Des Devel Ther. 2021 Jan 14:15:195-207. doi: 10.2147/DDDT.S291229. eCollection 2021.

Abstract

Local anesthetics have the advantage of complete analgesia with fewer side effects compared to systemic analgesics. However, their clinical use is limited due to their short duration of action. Thus, local anesthetics with fast onset, long duration of action, selective nociceptive block, and low local and systemic toxicity are highly desirable. In the past electrophysiological studies, quaternary lidocaine derivatives (QLDs) showed these characteristics. Here, we review electrophysiological properties of QLDs and their pharmacodynamic characteristics to shed light on potential problems.

Keywords: QX-314; derivatives; lidocaine; local anesthetics.

Publication types

  • Review

MeSH terms

  • Anesthetics, Local / adverse effects
  • Anesthetics, Local / therapeutic use*
  • Animals
  • Humans
  • Lidocaine / adverse effects
  • Lidocaine / therapeutic use*
  • Pain / drug therapy*
  • Pain Management

Substances

  • Anesthetics, Local
  • Lidocaine

Grants and funding

This work was supported by the National Science and Technology Major Project, Ministry of Science and Technology of the People’s Republic of China (No.2014ZX09101001-003), Beijing, China.