Immunoglobulin allotypes in caucasian and Chinese myasthenia gravis: differences from Japanese patients

H C Chiu; G G de Lange; N Willcox; A Vincent; J Newsom-Davis; K H Hsieh; T P Hung

doi:10.1136/jnnp.51.2.214

Immunoglobulin allotypes in caucasian and Chinese myasthenia gravis: differences from Japanese patients

J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):214-7. doi: 10.1136/jnnp.51.2.214.

Authors

H C Chiu¹, G G de Lange, N Willcox, A Vincent, J Newsom-Davis, K H Hsieh, T P Hung

Affiliation

¹ Department of Neurology, National Taiwan University Hospital, Taipei.

Abstract

The G2m(n) allotype was significantly increased in Chinese female and high autoantibody cases, and in caucasians with pure ocular myasthenia, or undetectable autoantibody. In contrast to the strong Glm(x) association reported in Japanese, no overall Gm haplotype, or Am or Km allotype association was found in 90 (Taiwan) Chinese and 181 caucasian myasthenia gravis patients.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
China
Ethnicity*
Female
Gene Frequency
Haplotypes
Humans
Immunoglobulin Gm Allotypes / genetics*
Japan
London
Male
Myasthenia Gravis / genetics*

Substances

Immunoglobulin Gm Allotypes