Risk of 28-day readmissions among stroke patients in Malaysia (2008-2015): Trends, causes and its associated factors

PLoS One. 2021 Jan 19;16(1):e0245448. doi: 10.1371/journal.pone.0245448. eCollection 2021.

Abstract

Background and objectives: Risk of readmissions is an important quality indicator for stroke care. Such information is limited among low- and middle-income countries. We assessed the trends for 28-day readmissions after a stroke in Malaysia from 2008 to 2015 and evaluated the causes and factors associated with readmissions in 2015.

Methods: Using the national hospital admission records database, we included all stroke patients who were discharged alive between 2008 and 2015 for this secondary data analysis. The risk of readmissions was described in proportion and trends. Reasons were coded according to the International Classification of Diseases, 10th Edition. Multivariable logistic regression was performed to identify factors associated with readmissions.

Results: Among 151729 patients, 11 to 13% were readmitted within 28 days post-discharge from their stroke events each year. The trend was constant for ischemic stroke but decreasing for hemorrhagic stroke. The leading causes for readmissions were recurrent stroke (32.1%), pneumonia (13.0%) and sepsis (4.8%). The risk of 28-day readmission was higher among those with stroke of hemorrhagic (adjusted odds ratio (AOR): 1.52) and subarachnoid hemorrhage (AOR: 2.56) subtypes, and length of index admission >3 days (AOR: 1.48), but lower among younger age groups of 35-64 (AORs: 0.61-0.75), p values <0.001.

Conclusion: The risk of 28-day readmission remained constant from 2008 to 2015, where one in eight stroke patients required readmission, mainly attributable to preventable causes. Age, ethnicity, stroke subtypes and duration of the index admission influenced the risk of readmission. Efforts should focus on minimizing potentially preventable admissions, especially among those at higher risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Malaysia / epidemiology
  • Male
  • Middle Aged
  • Odds Ratio
  • Patient Discharge
  • Patient Readmission*
  • Pneumonia / complications
  • Recurrence
  • Risk Factors
  • Sepsis / complications
  • Stroke / epidemiology*
  • Young Adult

Grants and funding

This study was funded by a grant from the Ministry of Health Malaysia – National Institute of Health grant under the project “Monitoring Stroke Burden in Malaysia: the use of linked national data sources” (NMRR-18-100-39847). WYH is supported by the Honours Track of MSc Epidemiology, University Medical Center Utrecht with a grant from the Netherlands Organization for Scientific Research (Grant number: 022.005.021). IV is funded by the Dutch Heart Foundation for project Facts and Figures. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.