Lead in Brazilian food: Exposure assessment and risk characterization

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Feb;38(2):315-325. doi: 10.1080/19440049.2020.1852321. Epub 2021 Jan 16.

Abstract

A risk assessment was performed to estimate the lead (Pb) dietary intake in the Brazilian population. Data on Pb concentration in food were obtained through a systematic review with meta-analyses and from the GEMS/Food database, both involving data through 2018. Food consumption data were obtained from a Brazilian official dietary survey. Pb dietary intakes were estimated by a deterministic approach. Risk characterisation was conducted using the margin of exposure approach (MOE). The total Pb intake in the Brazilian population ranged from 1.53 to 2.01 μg/kg bw/day. Major contributors to Pb dietary exposure were the vegetable and vegetable products and beverage categories. From the results obtained, a risk of increased systolic pressure, nephrotoxicity and decrease of 0.5 point intelligence quotient can be expected, MOE<1, with greater magnitudes of risk observed for men in rural areas and in the Midwest, Southeast and South Brazilian regions. The dietary risk assessment indicates a health concern for the Brazilian population associated with Pb dietary intake.

Keywords: Brazil; Risk assessment; food safety; inorganic contaminant; intake; meta-analysis; sanitary surveillance.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Brazil
  • Dietary Exposure / analysis*
  • Food Analysis*
  • Food Contamination / analysis*
  • Humans
  • Lead / analysis*
  • Risk Assessment

Substances

  • Lead