In this paper we formulate a multi-scale nested immuno-epidemiological model of HIV on complex networks. The system is described by ordinary differential equations coupled with a partial differential equation. First, we prove the existence and uniqueness of the immunological model and then establish the well-posedness of the multi-scale model. We derive an explicit expression of the basic reproduction number [Formula: see text] of the immuno-epidemiological model. The system has a disease-free equilibrium and an endemic equilibrium. The disease-free equilibrium is globally stable when [Formula: see text] and unstable when [Formula: see text]. Numerical simulations suggest that [Formula: see text] increases as the number of nodes in the network increases. Further, we find that for a scale-free network the number of infected individuals at equilibrium is a hump-like function of the within-host reproduction number; however, the dependence becomes monotone if the network has predominantly low connectivity nodes or high connectivity nodes.
Keywords: Age structured; Basic reproduction number; Epidemic model; HIV; Network.