Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5

Li Lei; Bei Yan; Panpan Liu; Jie Li; Chao Chen; Wu Zhu; Yehong Kuang; Xiang Chen; Cong Peng

doi:10.1038/s41392-020-00379-1

Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5

Signal Transduct Target Ther. 2021 Jan 15;6(1):19. doi: 10.1038/s41392-020-00379-1.

Authors

Li Lei^#^{1

2

3

4

5}, Bei Yan^#^{1

2

3

4

5}, Panpan Liu^{1

2

3

4

5}, Jie Li^{1

2

3

4

5}, Chao Chen^{1

2

3

4

5}, Wu Zhu^{1

2

3

4

5}, Yehong Kuang^{1

2

3

4

5}, Xiang Chen^{6

7

8

9

10}, Cong Peng^{11

12

13

14

15}

Affiliations

¹ The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
³ Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, China.
⁴ Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China.
⁵ Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China.
⁶ The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. chenxiangck@126.com.
⁷ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China. chenxiangck@126.com.
⁸ Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, China. chenxiangck@126.com.
⁹ Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China. chenxiangck@126.com.
¹⁰ Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China. chenxiangck@126.com.
¹¹ The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. pengcongxy@csu.edu.cn.
¹² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China. pengcongxy@csu.edu.cn.
¹³ Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, China. pengcongxy@csu.edu.cn.
¹⁴ Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, China. pengcongxy@csu.edu.cn.
¹⁵ Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, China. pengcongxy@csu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Keratinocytes / immunology*
Lysophospholipids / immunology*
Psoriasis / immunology*
Receptors, Lysophosphatidic Acid / immunology*

Substances

LPAR5 protein, human
Lysophospholipids
Receptors, Lysophosphatidic Acid
lysophosphatidic acid