RETRACTED: Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1/PUMA/FOXO3a deacetylation

Life Sci. 2021 Mar 15:269:119017. doi: 10.1016/j.lfs.2021.119017. Epub 2021 Jan 12.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figs. 2E, and 3C, which appear to have the same eyebrow shaped phenotype as many other publications tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0). The journal requested the corresponding author comment on these concerns and provide the raw data. However the authors were not able to satisfactorily fulfil this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Acetylation modification; Acute kidney injury; Apoptosis; FOXO3a; MicroRNA-183-3p; PUMA; SIRT1; Tubulointerstitial fibrosis.

Publication types

  • Retracted Publication

MeSH terms

  • Acetylation
  • Acute Kidney Injury / genetics*
  • Acute Kidney Injury / pathology*
  • Animals
  • Apoptosis
  • Apoptosis Regulatory Proteins / metabolism*
  • Base Sequence
  • Cell Line
  • Cell Proliferation
  • Down-Regulation / genetics
  • Epithelial Cells / metabolism
  • Epithelial-Mesenchymal Transition
  • Fibrosis
  • Forkhead Box Protein O3 / metabolism*
  • Gene Silencing
  • Kidney Tubules / metabolism
  • Kidney Tubules / pathology
  • Male
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Sirtuin 1 / metabolism*
  • Up-Regulation / genetics

Substances

  • Apoptosis Regulatory Proteins
  • Bbc3 protein, rat
  • FOXO3 protein, rat
  • Forkhead Box Protein O3
  • MIRN183 microRNA, rat
  • MicroRNAs
  • Sirtuin 1